Clemmensen Reduction Application. From wikipedia the free encyclopedia clemmensen reduction is a chemical reaction described as a reduction of ketones or aldehydes to alkanes using zinc amalgam and concentrated hydrochloric acid. Explanation the clemmensen reduction is used to conveniently reduce the carbonyl compounds which are stable to strongly acidic conditions to alkanes.
The mechanism of clemmensen reduction is not fully understood. The clemmensen reduction is an organic reaction used to reduce an aldehyde or ketone to an alkane using amalgamated zinc and hydrochloric acid. The reduction of carbonyl groups of aldehydes and ketones to methylene groups with amalgamated zinc and concentrated hydrochloric acid is known as clemmensen reduction.
Clemmensen reduction is one of the most powerful reduction methods in organic synthesis and many reviews have been published 3 8 10 generally zinc amalgam and highly concentrated hydrochloric acid under reflux are employed to suppress the formation of by products such as alcohols dimerization products including pinacols and related compounds.
The substrate must be stable to strong acid. The reduction of carbonyl groups of aldehydes and ketones to methylene groups with amalgamated zinc and concentrated hydrochloric acid is known as clemmensen reduction. The clemmensen reduction is an organic reaction used to reduce an aldehyde or ketone to an alkane using amalgamated zinc and hydrochloric acid. Intermediacy of radicals are implicated.
